EPIMERIC (20R,20S)-VERAZINE ISOLATED FROM VERATRUM-MAACKII - 2-DIMENSIONAL NMR-STUDIES AND TOTAL ASSIGNMENT OF H-1-RESONANCES AND C-13-RESONANCES

被引：17

作者：

HAN, XW ^{[1
]}

RUEGGER, H ^{[1
]}

机构：

[1] SPECTROSPIN AG,CH-8117 FALLANDEN,SWITZERLAND

来源：

PLANTA MEDICA | 1992年 / 58卷 / 05期

关键词：

VERATRUM-MAACKII; VERAZINE; STEREOCHEMICAL ELUCIDATION; NMR SPECTROSCOPY;

D O I：

10.1055/s-2006-961511

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

C-13-NMR evidence shows that verazine [(25S)-iminocholesta-5,22(N)-diene-3beta-ol] isolated from the Chinese plant Veratrum maackii (Melanthiaceae) consists of a 20R/20S mixture of epimers. The determination of the configurations at the chiral epimeric center and of the conformation of the 17beta-side chain is based on the total assignment of the C-13- and H-1-NMR resonances. This goal was achieved by the extensive use of homo- and heteronuclear shift correlation and two-dimensional NOE spectroscopy methods at high magnetic field.

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页码：449 / 453

页数：5

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