Stratification of the channel domain in neurotransmitter receptors

被引：75

作者：

Bertrand, Daniel ^{[1
]}

Galzi, Jean-Luc ^{[2
]}

Devillers-Thiery, Anne ^{[2
]}

Bertrand, Sonia ^{[1
]}

Changeux, Jean-Pierre ^{[2
]}

机构：

[1] Ctr Med Univ Geneva, Dept Physiol, CH-1211 Geneva 4, Switzerland

[2] Inst Pasteur, Unite Rech Associee, Ctr Natl Rech Sci D1284, F-74724 Paris 15, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 04期

关键词：

D O I：

10.1016/0955-0674(93)90141-C

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Analyses of the ionic pore of ligand-gated ion channels at the amino acid level reveal a structural and functional stratification of the M2 channel domain. Mutations in the equatorial and outer regions affect channel gating, whereas mutations of other amino acid rings alter ionic permeability or selectivity.

引用

页码：688 / 693

页数：6

共 38 条

[1] ACETYLCHOLINE-RECEPTOR CHANNEL STRUCTURE PROBED IN CYSTEINE-SUBSTITUTION MUTANTS
AKABAS, MH
STAUFFER, DA
XU, M
KARLIN, A
[J]. SCIENCE, 1992, 258 (5080) : 307 - 310
[2] UNCONVENTIONAL PHARMACOLOGY OF A NEURONAL NICOTINIC RECEPTOR MUTATED IN THE CHANNEL DOMAIN
BERTRAND, D
DEVILLERSTHIERY, A
REVAH, F
GALZI, JL
HUSSY, N
MULLE, C
BERTRAND, S
BALLIVET, M
CHANGEUX, JP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (04) : 1261 - 1265
[3] BERTRAND D, 1993, P NATL ACAD IN PRESS
[4] CONTROL BY ASPARAGINE RESIDUES OF CALCIUM PERMEABILITY AND MAGNESIUM BLOCKADE IN THE NMDA RECEPTOR
BURNASHEV, N
SCHOEPFER, R
MONYER, H
RUPPERSBERG, JP
GUNTHER, W
SEEBURG, PH
SAKMANN, B
[J]. SCIENCE, 1992, 257 (5075) : 1415 - 1419
[5] THE FUNCTIONAL ARCHITECTURE OF THE ACETYLCHOLINE NICOTINIC RECEPTOR EXPLORED BY AFFINITY LABELING AND SITE-DIRECTED MUTAGENESIS
CHANGEUX, JP
GALZI, JL
DEVILLERSTHIERY, A
BERTRAND, D
[J]. QUARTERLY REVIEWS OF BIOPHYSICS, 1992, 25 (04) : 395 - 432
[6] THE FALL AND RISE OF NEURONAL ALPHA-BUNGAROTOXIN BINDING-PROTEINS
CLARKE, PBS
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (11) : 407 - 413
[7] TRIS+/NA+ PERMEABILITY RATIOS OF NICOTINIC ACETYLCHOLINE-RECEPTORS ARE REDUCED BY MUTATIONS NEAR THE INTRACELLULAR END OF THE M2 REGION
COHEN, BN
LABARCA, C
CZYZYK, L
DAVIDSON, N
LESTER, HA
[J]. JOURNAL OF GENERAL PHYSIOLOGY, 1992, 99 (04) : 545 - 572
[8] STRATIFIED ORGANIZATION OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR CHANNEL
DEVILLERSTHIERY, A
GALZI, JL
BERTRAND, S
CHANGEUX, JP
BERTRAND, D
[J]. NEUROREPORT, 1992, 3 (11) : 1001 - 1004
[9] CA2+ PERMEABILITY OF UNEDITED AND EDITED VERSIONS OF THE KAINATE SELECTIVE GLUTAMATE RECEPTOR GLUR6
EGEBJERG, J
HEINEMANN, SF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) : 755 - 759
[10] REGIONS OF BETA-4.BETA-2 SUBUNIT CHIMERAS THAT CONTRIBUTE TO THE AGONIST SELECTIVITY OF NEURONAL NICOTINIC RECEPTORS
FIGL, A
COHEN, BN
QUICK, MW
DAVIDSON, N
LESTER, HA
[J]. FEBS LETTERS, 1992, 308 (03) : 245 - 248

← 1 2 3 4 →