EFFECT OF CONDITIONED FEAR STRESS ON SEROTONIN METABOLISM IN THE RAT-BRAIN

被引：88

作者：

INOUE, T

KOYAMA, T

YAMASHITA, I

机构：

[1] Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Kita-ku, Sapporo, 060

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 44卷 / 02期

关键词：

SEROTONIN; 5-HIAA; TRYPTOPHAN; CONDITIONED FEAR STRESS; FREEZING BEHAVIOR; FOOT-SHOCK STRESS; MEDIAL PREFRONTAL CORTEX;

D O I：

10.1016/0091-3057(93)90476-A

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of electric foot-shock stress (EFS) and conditioned fear stress (CFS) on serotonin [5-hydroxytryptamine (5-HT)] metabolism in seven various brain regions of the rat were studied by measuring tryptophan, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA). EFS for 30 min increased tryptophan levels in almost all brain regions but did not change 5-HT levels in any regions. It increased 5-HIAA levels in the medial prefrontal cortex (mPFC), nucleus accumbens, and amygdala. CFS (exposure to an environment paired previously with foot-shock) increased defecation and induced freezing behavior. It failed to change tryptophan and 5-HT levels in any brain regions but increased 5-HIAA level only in the mPFC. In contrast to EFS, which increased 5-HT metabolism in several other brain regions, increased metabolism of 5-HT was especially marked in the mPFC after CFS, regarded as psychological stress.

引用

页码：371 / 374

页数：4

共 29 条

[1] CHRONIC STRESS INCREASES SEROTONIN AND NORADRENALINE IN RAT-BRAIN AND SENSITIZES THEIR RESPONSES TO A FURTHER ACUTE STRESS [J].