A 3-DIMENSIONAL MODEL FOR THE INTERACTION OF MSH WITH THE MELANOCORTIN-1 RECEPTOR

被引：55

作者：

PRUSIS, P

FRANDBERG, PA

MUCENIECE, R

KALVINSH, I

WIKBERG, JES

机构：

[1] UPPSALA UNIV,DEPT PHARMACEUT PHARMACOL,S-75124 UPPSALA,SWEDEN

[2] LATVIAN ACAD SCI,INST ORGAN SYNTH,PHARMACOL LAB,RIGA 226006,LATVIA

[3] LATVIAN ACAD SCI,INST ORGAN SYNTH,DEPT MED CHEM,RIGA 226006,LATVIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 210卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1647

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling using bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into a binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in TM3 of receptor with histidine in cyclic MSH-peptide, H260 in TM6 with glutamic in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data. (C) 1995 Academic Press, Inc.

引用

页码：205 / 210

页数：6

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