RELATION BETWEEN EXPOSURE TO FLUORIDE AND BRONCHIAL RESPONSIVENESS IN ALUMINUM POTROOM WORKERS WITH WORK-RELATED ASTHMA-LIKE SYMPTOMS

被引:36
作者
SOYSETH, V
KONGERUD, J
EKSTRAND, J
BOE, J
机构
[1] UNIV OSLO,RIKSHOSP,DEPT THORAC MED,OSLO,NORWAY
[2] KAROLINSKA INST,DEPT DENT TOXICOL,HUDDINGE,SWEDEN
关键词
D O I
10.1136/thx.49.10.984
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background - The relation between plasma fluoride levels and bronchial responsiveness was investigated in a longitudinal study in aluminium potroom workers who reported work-related asthmatic symptoms. Methods - From a cross-sectional respiratory survey, 26 men who reported work-related asthmatic symptoms on a validated questionnaire were selected for repeated measurements of bronchial responsiveness to methacholine. Regular analyses of plasma fluoride levels were performed. Exposure to fluoride and total particulates was assessed from routine surveillance of the workplace. Bronchial responsiveness was expressed as the dose-response slope of the line through the origin and last data point. Results - A positive association was found between bronchial responsiveness and plasma fluoride levels, such that an increase in the plasma fluoride level of 10 ng/ml was associated with an increase in the dose-response slope by a factor of 1.11 (95% confidence interval 1.05 to 1.17). Plasma fluoride levels were associated with the total atmospheric fluoride concentration in mg/m(3) (beta = 28.1), but not with total particulates in the environment. Conclusions - Bronchial responsiveness in aluminium potroom workers reporting work-related asthmatic symptoms appears to be related to plasma levels of fluoride. The underlying mechanism is, however, unknown.
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页码:984 / 989
页数:6
相关论文
共 34 条
[1]   DOES ALUMINUM SMELTING CAUSE LUNG-DISEASE [J].
ABRAMSON, MJ ;
WLODARCZYK, JH ;
SAUNDERS, NA ;
HENSLEY, MJ .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 139 (04) :1042-1057
[2]  
BURGE PS, 1982, EUR J RESPIR DIS, V63, P91
[3]   AIRWAY HYPERRESPONSIVENESS AND LATE ASTHMATIC RESPONSES [J].
COCKCROFT, DW .
CHEST, 1988, 94 (01) :178-180
[4]   BRONCHIAL REACTIVITY TO INHALED HISTAMINE - METHOD AND CLINICAL SURVEY [J].
COCKCROFT, DW ;
KILLIAN, DN ;
MELLON, JJA ;
HARGREAVE, FE .
CLINICAL ALLERGY, 1977, 7 (03) :235-243
[5]   THE TEMPORAL RELATIONSHIP BETWEEN INCREASES IN AIRWAY RESPONSIVENESS TO HISTAMINE AND LATE ASTHMATIC RESPONSES INDUCED BY OCCUPATIONAL AGENTS [J].
DURHAM, SR ;
GRANEEK, BJ ;
HAWKINS, R ;
TAYLOR, AJN .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1987, 79 (02) :398-406
[6]   OCCUPATIONAL FLUORIDE EXPOSURE AND PLASMA FLUORIDE LEVELS IN MAN [J].
EHRNEBO, M ;
EKSTRAND, J .
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 1986, 58 (03) :179-190
[7]   MICROMETHOD FOR DETERMINATION OF FLUORIDE IN BLOOD-PLASMA AND SALIVA [J].
EKSTRAND, J .
CALCIFIED TISSUE RESEARCH, 1977, 23 (03) :225-228
[8]   ASTHMA, ASTHMALIKE SYMPTOMS, CHRONIC-BRONCHITIS, AND THE DEGREE OF BRONCHIAL HYPERRESPONSIVENESS IN EPIDEMIOLOGIC SURVEYS [J].
ENARSON, DA ;
VEDAL, S ;
SCHULZER, M ;
DYBUNCIO, A ;
CHANYEUNG, M .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1987, 136 (03) :613-617
[9]   BRONCHOALVEOLAR NEUTROPHILIA DURING LATE ASTHMATIC REACTIONS INDUCED BY TOLUENE DIISOCYANATE [J].
FABBRI, LM ;
BOSCHETTO, P ;
ZOCCA, E ;
MILANI, G ;
PIVIROTTO, F ;
PLEBANI, M ;
BURLINA, A ;
LICATA, B ;
MAPP, CE .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1987, 136 (01) :36-42
[10]  
FROSTAD EW, 1936, TIDSSKR NOR LAEGEFOR, V56, P79