MODULATORY ACTIONS OF GAMMA-AMINOBUTYRIC-ACID (GABA) ON GABA TYPE-A RECEPTOR SUBUNIT EXPRESSION AND FUNCTION

被引：51

作者：

SCHOUSBOE, A ^{[1
]}

REDBURN, DA ^{[1
]}

机构：

[1] UNIV TEXAS,SCH MED,DEPT ANAT & NEUROBIOL,HOUSTON,TX

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1995年 / 41卷 / 01期

关键词：

GABA; GABA RECEPTORS; DEVELOPMENT; BRAIN; RETINA;

D O I：

10.1002/jnr.490410102

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gamma aminobutyric acid (GABA) is present in the central nervous system (CNS) during very early embryogenesis. It is therefore likely to play a role not only as a neurotransmitter but also as a signal molecule for neuronal differentiation, growth, and development, It has been firmly established that formation of synapses is strengthened by GABA, and the expression of certain subunits of the GABA type A (GABA(A)) receptor complex is clearly promoted by GABA, This latter effect of GABA may have profound implications for the functional activity of GABAergic synapses since the pharmacological properties of GABA(A) receptors are governed by the subunit composition of the receptor complex, Dynamic changes in GABA(A) receptor expression and diversity during development and differentiation may therefore play important roles for the inhibitory potential of the CNS during mature stages. (C) 1995 Wiley-Liss, Inc.

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页码：1 / 7

页数：7

相关论文

共 72 条

[1] INDUCTION OF LOW-AFFINITY GABA(A) RECEPTORS BY THE GABA-AGONIST THIP (4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL) IN CULTURED RAT CEREBELLAR GRANULE CELLS IS PREVENTED BY INHIBITION OF POLYAMINE BIOSYNTHESIS [J].

ABRAHAM, JH ;

SEILER, N ;

SCHOUSBOE, A .

JOURNAL OF NEUROSCIENCE RESEARCH, 1994, 39 (06) :656-662

[2] A-G PROTEIN COUPLES SEROTONIN AND GABA-B RECEPTORS TO THE SAME CHANNELS IN HIPPOCAMPUS [J].

ANDRADE, R ;

MALENKA, RC ;

NICOLL, RA .

SCIENCE, 1986, 234 (4781) :1261-1265

[3]

ANGELOTTI TP, 1993, J NEUROSCI, V13, P1429

[4]

ANGELOTTI TP, 1993, J NEUROSCI, V13, P1418

[5] GABA AGONIST PROMOTED FORMATION OF LOW AFFINITY GABA RECEPTORS ON CEREBELLAR GRANULE CELLS IS RESTRICTED TO EARLY DEVELOPMENT [J].

BELHAGE, B ;

HANSEN, GH ;

SCHOUSBOE, A ;

MEIER, E .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1988, 6 (02) :125-128

[6] DEPOLARIZATION BY K+ AND GLUTAMATE ACTIVATES DIFFERENT NEUROTRANSMITTER RELEASE MECHANISMS IN GABAERGIC NEURONS - VESICULAR VERSUS NONVESICULAR RELEASE OF GABA [J].

BELHAGE, B ;

HANSEN, GH ;

SCHOUSBOE, A .

NEUROSCIENCE, 1993, 54 (04) :1019-1034

[7] GABA AGONIST INDUCED CHANGES IN ULTRASTRUCTURE AND GABA RECEPTOR EXPRESSION IN CEREBELLAR GRANULE CELLS IS LINKED TO HYPERPOLARIZATION OF THE NEURONS [J].

BELHAGE, B ;

HANSEN, GH ;

SCHOUSBOE, A .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1990, 8 (04) :473-479

[8] EFFECTS OF INHIBITORS OF PROTEIN-SYNTHESIS AND INTRACELLULAR-TRANSPORT ON THE GAMMA-AMINOBUTYRIC-ACID AGONIST-INDUCED FUNCTIONAL-DIFFERENTIATION OF CULTURED CEREBELLAR GRANULE CELLS [J].

BELHAGE, B ;

HANSEN, GH ;

MEIER, E ;

SCHOUSBOE, A .

JOURNAL OF NEUROCHEMISTRY, 1990, 55 (04) :1107-1113

[9] MECHANISM OF ANION PERMEATION THROUGH CHANNELS GATED BY GLYCINE AND GAMMA-AMINOBUTYRIC-ACID IN MOUSE CULTURED SPINAL NEURONS [J].

BORMANN, J ;

HAMILL, OP ;

SAKMANN, B .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 385 :243-286

[10] EXPRESSION PATTERNS OF GAMMA-AMINOBUTYRIC-ACID TYPE-A RECEPTOR SUBUNIT MESSENGER-RNAS IN PRIMARY CULTURES OF GRANULE NEURONS AND ASTROCYTES FROM NEONATAL RAT CEREBELLA [J].

BOVOLIN, P ;

SANTI, MR ;

PUIA, G ;

COSTA, E ;

GRAYSON, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) :9344-9348

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