IS TUBAL-LIGATION A RISK FACTOR FOR LOW BONE-DENSITY AND INCREASED RISK OF FRACTURE

被引:10
作者
FOX, KM
CUMMINGS, SR
机构
[1] UNIV CALIF SAN FRANCISCO,DIV GEN INTERNAL MED,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT EPIDEMIOL & BIOSTAT,SAN FRANCISCO,CA 94143
关键词
TUBAL LIGATION; BONE DENSITY; APPENDICULAR SKELETON; POSTMENOPAUSAL WOMEN;
D O I
10.1016/0002-9378(95)90092-6
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Osteoporosis is a major women's health problem, because it is responsible for about 1.3 million fractures in the United States each year. Estrogen deficiency is a major risk factor in the pathogenesis of osteoporosis. Recent evidence has indicated that tubal ligation may cause menstrual dysfunction and estrogen deficiency. This study examined the association between tubal ligation and bone mass in a group of elderly postmenopausal women. STUDY DESIGN: Subjects were 2215 white women greater than or equal to 65 years old participating in the Baltimore center of the Study of Osteoporotic Fractures, Bone mineral density of the proximal and distal radius and the calcaneus was measured by single photon absorptiometry. Multiple regression analysis was performed to determine whether tubal ligation had an independent effect on bone density. The effect of tubal ligation on the risk of hip and osteoporotic fractures was estimated by Cox proportional hazards model. RESULTS: Women who reported a tubal ligation had lower, although not statistically significant, bone density of the radius and calcaneus. The relative risk of hip (1.05, 95% confidence limit 0.84 to 1.32) and osteoporotic fractures (1.01, 0.80 to 1.29) was not significantly increased in women with tubal ligation. CONCLUSION: We conclude that elderly women who had a tubal ligation have small changes in bone density that are not of sufficient magnitude to increase their risk of osteoporotic fractures.
引用
收藏
页码:101 / 105
页数:5
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