APOLIPOPROTEIN E4 ALLELE FREQUENCY IN SPANISH ALZHEIMER AND CONTROL CASES

被引：44

作者：

ADROER, R

SANTACRUZ, P

BLESA, R

LOPEZPOUSA, S

ASCASO, C

OLIVA, R

机构：

[1] UNIV BARCELONA, FAC MED, HUMAN GENOME & MOLEC GENET RES GRP, E-08028 BARCELONA, SPAIN

[2] HOSP CLIN BARCELONA, NEUROL SERV, BARCELONA, SPAIN

[3] HOSP SANTA CATERINA, DEMENTIA ASSESSMENT UNIT, GIRONA, SPAIN

[4] UNIV BARCELONA, HOSP CLIN & PROV, EPIDEMIOL & BIOSTAT UNIT, BARCELONA, SPAIN

来源：

NEUROSCIENCE LETTERS | 1995年 / 189卷 / 03期

关键词：

ALZHEIMERS DISEASE; APOLIPOPROTEIN E; GENOTYPE; APOE; AMYLOID;

D O I：

10.1016/0304-3940(95)11480-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have found an APOE epsilon 4 allelic frequency of 0.289 (95% CI 0.195-0.383) in Spanish AD patients (n= 88; average age = 71.2 +/- 9.37) and of 0.061 (95% CI 0.023-0.099) in age-matched controls (n = 147; average age = 71.5 +/- 10.29). Remarkably no ApoE 4/4 subjects were observed in any of the age-matched control groups compared to a total of 22 AD patients with the ApoE 4/4 phenotype. The combined odds ratio for subjects with one or two epsilon 4 alleles in the present study is 6.25 (95% CI 3.13-12.60), which is one of the highest so far reported. Altogether our results suggest a trans-European difference in the ApoE epsilon 4 frequency but no differences in the strength of the association between APOE4 and AD.

引用

页码：182 / 186

页数：5

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