ORIGIN OF TRIPLOIDY AND TETRAPLOIDY IN MAN - 11 CASES WITH CHROMOSOME MARKERS

被引：89

作者：

KAJII, T ^{[1
]}

NIIKAWA, N ^{[1
]}

机构：

[1] UNIV GENEVA, GYNECOL & OBSTET CLIN, EMBRYOL & CYTOGENET LAB, CH-1211 GENEVA, SWITZERLAND

来源：

CYTOGENETICS AND CELL GENETICS | 1977年 / 18卷 / 03期

关键词：

D O I：

10.1159/000130756

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sixteen triploid and 1 tetraploid human abortuses were studied for the origin of polyploidy using a sequential Q- and R-banding technique. Ten triploid abortuses provided informative data; 1 originated in the maternal 1st meiotic division; 5 apparently resulted from dispermy; 2 derived from an error during either the paternal 2nd meiotic division or the 2st mitotic division; and the last 2 were of paternal origin. Paternal factors, especially dispermy, may be the predominant sources of triploidy in man. The tetraploid abortus showed duplication of both the maternal and paternal haploid sets, suggesting normal division of chromosomes and suppression of cytoplasmic cleavage at the 1st mitotic division. No correlation was found between the origin of polyploidy and the phenotype of the triploid abortuses, nor between the origin of polyploidy and the maternal use of oral contraceptives.

引用

页码：109 / 125

页数：17

共 38 条

[1] CHROMOSOME STUDIES IN INVESTIGATION OF STILLBIRTHS AND NEONATAL DEATHS [J].

BAULD, R ;

SUTHERLAND, GR ;

BAIN, AD .

ARCHIVES OF DISEASE IN CHILDHOOD, 1974, 49 (10) :782-786

[2]

Beatty RA, 1957, PARTHENOGENESIS POLY

[3] HYDATIDIFORM MOLE AND COEXISTENT FOETUS BOTH WITH TRIPLOID CHROMOSOME CONSTITUTION [J].

BETSCHER, NA ;

FORTUNE, DW ;

FITZGERA.MG .

BMJ-BRITISH MEDICAL JOURNAL, 1967, 3 (5563) :476-+

[4]

BOUE A, 1974, PHYSIOLOGY GENETIC B, P317

[5]

Boue J., 1975, Aging Gametes: Their Biology and Pathology, P330

[6]

BUTLER L J, 1969, Journal of Medical Genetics, V6, P413, DOI 10.1136/jmg.6.4.413

[7]

CARR DH, 1970, CAN MED ASSOC J, V103, P343

[8] CYTOGENETIC STUDY OF HUMAN SPONTANEOUS ABORTIONS USING BANDING TECHNIQUES [J].

CREASY, MR ;

CROLLA, JA ;

ALBERMAN, ED .

HUMAN GENETICS, 1976, 31 (02) :177-196

[9]

DHADIAL RK, 1970, LANCET, V2, P20

[10] 3 CASES OF TRIPLOIDY IN MAN [J].

EDWARDS, JH ;

YUNCKEN, C ;

RUSHTON, DI ;

RICHARDS, S ;

MITTWOCH, U .

CYTOGENETICS, 1967, 6 (02) :81-+

← 1 2 3 4 →