ASPIRIN AND GASTRO-INTESTINAL BLEEDING - INTEREST OF PLASMA SALICYLATE DETERMINATION

From history-taking and from analysis of plasma salicylate levels it is shown that a link exists between aspirin and gastrointestinal bleeding in 68% of cases. Salicylate levels alone indicate that aspirin has been taken in 22% of cases. Plasma salicylate measurement and endoscopy allow a better understanding of haemorrhagic lesions due to aspirin. Aspirin is responsible especially for haemorrhage from ulcers and acute gastritis or duodenitis. Aspirin is seen to be dangerous in a moderate number of susceptible individuals: Those with peptic ulcer constitution or cirrhosis. © 1979 S. Karger AG, Basel.