INVOLVEMENT OF SPECTRIN IN MEMBRANE-FUSION - INDUCTION OF FUSION IN HUMAN ERYTHROCYTE-GHOSTS BY PROTEOLYTIC-ENZYMES AND ITS INHIBITION BY ANTI-SPECTRIN ANTIBODY

被引：27

作者：

LALAZAR, A

LOYTER, A

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 01期

关键词：

D O I：

10.1073/pnas.76.1.318

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In contrast to intact human erythrocytes, human erythrocyte ghosts can be agglutinated but not fused by Sendai virus. Membrane fusion can, however, be induced in virus-agglutinated erythrocyte ghosts by addition of proteolytic enzymes such as trypsin, papain, or Pronase. When erythrocyte ghosts were reacted with antispectrin antiserum, the antiserum inhibited both the induction of fusion and the proteolysis of the membrane spectrin. The correlation between the membrane fusion process and the membrane cytoskeleton is discussed.

引用

页码：318 / 322

页数：5

共 28 条

[1]

AHKONG QF, 1975, NATURE, V256, P208, DOI 10.1038/256208a0

[2]

BACHI T, 1977, CELL SURFACE REV VIR, V2, P83

[3] ROLE OF SULFHYDRYL GROUPS IN ERYTHROCYTE-MEMBRANE STRUCTURE [J].