ANTAGONISM OF ETHANOL INTOXICATION IN RATS BY INHIBITORS OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE

被引：16

作者：

MEFFORD, IN ^{[1
]}

LISTER, RG ^{[1
]}

OTA, M ^{[1
]}

LINNOILA, M ^{[1
]}

机构：

[1] NIAAA,DICBR,CLIN STUDIES LAB,BETHESDA,MD

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1990年 / 14卷 / 01期

关键词：

D O I：

10.1111/j.1530-0277.1990.tb00446.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The probable involvement of brain epinephrine in the expression of the acute sedative and intoxicating effects of ethanol and pentobarbital is demonstrated. Two selective inhibitors of phenylethanolamine N‐methyltransferase (PNMT), LY 134046 and LY78335, proved to be potent and long‐lasting antagonists of ethanol intoxication in rats. Acute antagonism of pentobarbital‐induced intoxication was observed with LY 134046. The present results are compatible with role for central epinephrine synthesis in ethanol and pentobarbital‐induced sedation and intoxication in rats. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：53 / 57

页数：5

共 44 条

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