EFFECTS OF WEIGHT-LOSS ON SUBSTRATE OXIDATION, ENERGY-EXPENDITURE, AND INSULIN SENSITIVITY IN OBESE INDIVIDUALS

被引:50
作者
FRANSSILAKALLUNKI, A
RISSANEN, A
EKSTRAND, A
OLLUS, A
GROOP, L
机构
[1] HELSINKI UNIV HOSP, DEPT MED 4, UNIONINKATU 38, SF-00170 HELSINKI, FINLAND
[2] HELSINKI UNIV HOSP, DEPT PSYCHIAT, HELSINKI, FINLAND
[3] HELSINKI UNIV HOSP, MEILAHTI HOSP, SF-00170 HELSINKI, FINLAND
关键词
OBESITY; VERY-LOW-CALORIE DIET; ENERGY METABOLISM; WEIGHT REDUCTION;
D O I
10.1093/ajcn/55.2.356
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
To evaluate the effect of weight loss on substrate oxidation, energy expenditure, and insulin sensitivity we studied 12 obese subjects (body mass index 33.4 +/- 1.1) before and after 6 wk of a very-low-calorie diet (VLCD) with euglycemic insulin clamp in combination with indirect calorimetry. Body weight decreased from 105.3 +/- 4.6 to 94.1 +/- 4.0 kg (P < 0.001) and fat mass from 47.2 +/- 3.6 to 37.7 +/- 3.0 kg (P < 0.001). Total glucose disposal during insulin clamp increased from 30.4 +/- 4.3 to 38.4 +/- 4.4-mu-mol.kg lean body mass (LBM)-1. min-1 (P < 0.05), insulin-stimulated glucose oxidation from 14.3 +/- 4.6 to 19.1 +/- 1.4-mu-mol.kg LBM-1.min-1 (P < 0.05), and non-oxidative glucose metabolism from 16.0 +/- 3.8 to 19.3 +/- 3.6-mu-mol.kg LBM-1. min-1 (NS). Lipid oxidation decreased in the basal state (P < 0.05) and during the insulin clamp (P < 0.01). The basal rate of energy expenditure decreased from 99.1 +/- 4.6 to 88.5 +/- 2.7 kJ.kg LBM-1. min-1 (P < 0.05) after weight reduction. A reduction in fat mass achieved by VLCD is associated with reduced lipid oxidation and, because of substrate competition, enhanced glucose oxidation. The physiological consequence is improved insulin sensitivity.
引用
收藏
页码:356 / 361
页数:6
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