IGG MONOCLONAL PROTEINS FROM PATIENTS WITH AXONAL PERIPHERAL NEUROPATHIES BIND TO DIFFERENT EPITOPES OF THE 68 KDA NEUROFILAMENT PROTEIN

被引：20

作者：

FAZIO, R ^{[1
]}

NEMNI, R ^{[1
]}

QUATTRINI, A ^{[1
]}

LORENZETTI, I ^{[1
]}

CANAL, N ^{[1
]}

机构：

[1] UNIV MILAN,IST SCI S RAFFAELE,DEPT NEUROL,I-20122 MILAN,ITALY

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 36卷 / 2-3期

关键词：

IGG MONOCLONAL PROTEIN; AXONAL PERIPHERAL NEUROPATHY; NEUROFILAMENT PROTEIN;

D O I：

10.1016/0165-5728(92)90041-I

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe three patients with a sensorimotor, axonal polyneuropathy and an IgG M-protein that binds to a 68 kDa axonal protein identified as the low molecular weight neurofilament protein (NF-I.). The immunological studies revealed that the M-proteins have different target epitopcs: one is phosphorylated and the other two are nonphosphorylated. One of the nonphosphorylated epitopes is common to other intermediate filaments, such as desmin and vimentin.

引用

页码：97 / 104

页数：8

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