STABILIZATION OF HUMAN RHINOVIRUS SEROTYPE-2 AGAINST PH-INDUCED CONFORMATIONAL CHANGE BY ANTIVIRAL COMPOUNDS

被引：46

作者：

GRUENBERGER, M

PEVEAR, D

DIANA, GD

KUECHLER, E

BLAAS, D

机构：

[1] UNIV VIENNA,INST BIOCHEM,WAHRINGERSTR 17,A-1090 VIENNA,AUSTRIA

[2] STERLING RES GRP,DEPT VIROL & ONCOPHARMACOL,RENSSELAER,NY 12144

[3] STGRLING RES GRP,DEPT MED CHEM,RENSSELAER,NY 12144

来源：

JOURNAL OF GENERAL VIROLOGY | 1991年 / 72卷

关键词：

D O I：

10.1099/0022-1317-72-2-431

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Four WIN compounds with anti-picornavirus activities were tested for their ability to stabilize human rhinovirus serotype 2 (HRV-2) against low pH-induced conformational changes in vitro, as determined by specific immunoprecipitation. These results were compared to the minimal inhibitory concentration (MIC) as measured in a plaque reduction assay. A direct relationship was observed between the concentration of the compound that prevented the low pH-induced conformational changes and the MIC, indicating that stabilization is an important element in the mode of action of these drug against HRV-2.

引用

页码：431 / 433

页数：3

共 14 条

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