EFFECT OF NON-AGGREGATING PROTEINS UPON THE GELATION OF SICKLE-CELL HEMOGLOBIN - MODEL CALCULATIONS AND DATA-ANALYSIS

被引：39

作者：

ROSS, PD ^{[1
]}

MINTON, AP ^{[1
]}

机构：

[1] NIAMDD,BIOCHEM PHARMACOL LAB,BETHESDA,MD 20014

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)91123-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The scaled particle theory for mixtures of hard spheres is used to calculate the effect of added proteins of varying size upon the solubility of sickle cell hemoglobin. For a given added weight, smaller macromolecules are more effective in lowering the solubility of sickle cell hemoglobin. Calculations based upon this model agree with many recently reported observations. The observed effect of the addition of myoglobin or hemoglobin α-chains on the minimum gelling concentration of sickle cell hemoglobin (Benesch et al.), however, is smaller than predicted. We suggest that this difference may arise from self-association of the added species. © 1979.

引用

页码：1308 / 1314

页数：7

共 17 条

[1] SICKLE HEMOGLOBIN GELATION - REACTION ORDER AND CRITICAL NUCLEUS SIZE [J].