CERTAIN N-TERMINAL PEPTIDES INHIBIT UPTAKE OF MATURE ASPARTATE-AMINOTRANSFERASE BY ISOLATED-MITOCHONDRIA

被引：3

作者：

BARILE, M

GIANNATTASIO, S

MARRA, E

PASSARELLA, S

PUCCI, P

SANNIA, G

QUAGLIARIELLO, E

机构：

[1] CNR,CTR STUDI MITOCONDRI METAB ENERGET,I-70126 BARI,ITALY

[2] NAPLES UNIV,DIPARTIMENTO CHIM ORGAN & BIOL,I-80138 NAPLES,ITALY

[3] UNIV BASILICATA,IST CHIM,POTENZA,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 170卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)92135-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To gain insight into the uptake of mature aspartate aminotransferase by isolated mitochondria, the capability of certain cyanogen bromide peptides from mature beef heart mitochondrial aspartate aminotransferase to inhibit enzyme uptake was kinetically tested. N-terminal peptides (1-9 and 10-31) proved to inhibit the rate of aspartate aminotransferase uptake respectively in purely competitive and non-competitive ways, whereas other peptides distal from the N-terminus (203-217, 321-327 and 328-353) were found to be completely ineffective. © 1990.

引用

页码：609 / 615

页数：7

共 23 条

[1] BIOGENESIS OF MITOCHONDRIA [J].