DEUTERIUM NMR-STUDIES OF CEREBROSIDE-PHOSPHOLIPID BILAYERS

被引：22

作者：

NEURINGER, LJ ^{[1
]}

SEARS, B ^{[1
]}

JUNGALWALA, FB ^{[1
]}

机构：

[1] EK SHRIVER CTR MENTAL RETARDAT,WALTHAM,MA 02154

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 558卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

!sup]2[!/sup]H-NMR; Cerebroside-phospholipid bilayer; Dipalmitoylphosphatidylcholine; Hydrogen bonding;

D O I：

10.1016/0005-2736(79)90268-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2H-NMR was used to probe the interaction of non-hydroxy fatty acid cerebroside and 2-hydroxy fatty acid cerebroside with the polar head group and with the acyl chains of dipalmitoylphosphatidylcholine in unsonicated bilayers. It is shown that the interior of the bilayer exhibits uniformly increasing orientational order as the concentration of both types of cerebroside increases, whereas the surface of the bilayer, as reflected by the head group motion, becomes disordered. The extent of the disorder at the surface is dependent upon the type and concentration of the cerebroside. These results are discussed in terms of hydrogen-bonding interactions. © 1979.

引用

页码：325 / 329

页数：5

共 16 条

[1] MOLECULAR ARRANGEMENTS IN GLYCOSPHINGOLIPIDS [J].