ADMINISTRATION OF CARBAMAZEPINE IN THE NUCLEUS OF THE SOLITARY TRACT INHIBITS THE ANTIHYPERTENSIVE EFFECT OF CLONIDINE

被引：5

作者：

MOSQUEDAGARCIA, R ^{[1
]}

OATES, JA ^{[1
]}

APPALSAMY, M ^{[1
]}

ROBERTSON, D ^{[1
]}

机构：

[1] VANDERBILT UNIV, DEPT PHARMACOL, NASHVILLE, TN 37232 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 197卷 / 2-3期

关键词：

BRAIN-STEM; ALPHA-2-ADRENOCEPTOR AGONISTS; BLOOD PRESSURE REGULATION; NUCLEUS-TRACTUS-SOLITARII; SPONTANEOUSLY HYPERTENSIVE RAT (SHR); CARBAMAZEPINE; CLONIDINE;

D O I：

10.1016/0014-2999(91)90524-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of carbamazepine administration into the nucleus tractus solitarii (NTS) on central alpha-2-adrenergic cardiovascular function were studied in normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR). Stereotaxic microinjections of carbamazepine (288 ng/60 nl) into the NTS of SHR transiently increased blood pressure, heart rate, and renal sympathetic nerve activity. These effects were followed by a modest depressor and bradycardic effect, with no change in sympathetic nerve activity. In addition, previous intra-NTS administration of carbamazepine attenuated the antihypertensive effect of the centrally acting alpha-2-adrenoceptor agonist, clonidine. Similar carbamazepine effects were observed in the WKY rats. These results suggest that some of the cardiovascular changes observed during carbamazepine treatment involve antagonism of central noradrenergic mechanisms.

引用

页码：213 / 216

页数：4

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