PARENCHYMAL PREAMYLOID AND AMYLOID DEPOSITS IN THE BRAINS OF PATIENTS WITH HEREDITARY CEREBRAL-HEMORRHAGE WITH AMYLOIDOSIS - DUTCH TYPE

被引：37

作者：

TIMMERS, WF

TAGLIAVINI, F

HAAN, J

FRANGIONE, B

机构：

[1] NYU MED CTR,DEPT PATHOL,560 1ST AVE,NEW YORK,NY 10016

[2] UNIV HOSP LEYDEN,DEPT NEUROL,LEIDEN,NETHERLANDS

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 02期

关键词：

Alzheimer's disease; Amyloid; β-protein; Dementia; Hereditary cerebral hermorrhage with amyloidosis-Dutch type; Immunohistochemistry; Stroke;

D O I：

10.1016/0304-3940(90)90632-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hereditary cerebral hermorrhage with amyloidosis-Dutch type, one of the 'cerebral β-amyloid diseases', like Alzheimer's disease, is characterized by extensive deposition of amyloid in small cerebral vessels. We investigated the presence of parenchymal β-protein deposits in two Dutch patients with hereditary cerebral hemorrhage with amyloidosis. Immunostaining with anti-SP28 revealed a full spectrum of these deposits, varying from preamyloid deposits to burned-out plaques. However, their density is less than in Alzheimer's desease, and immunostaining with Alz50 and anti-PHF did not show abnormal neurites in and around amyloid deposits in these two patients. © 1990.

引用

页码：223 / 226

页数：4

共 18 条

[1] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].