THE CHEMISTRY OF 1,1'-THIOBIS-(2-CHLOROETHANE) (SULFUR MUSTARD) .1. SOME SIMPLE DERIVATIVES

被引:32
作者
BLACK, RM
BREWSTER, K
HARRISON, JM
STANSFIELD, N
机构
[1] Chemical and Biological Defence Establishment, Porton Down, Salisbury, Wilts
来源
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1992年 / 71卷 / 1-4期
关键词
THIOBIS(2-CHLOROETHANE) AND DERIVATIVES; ANALYSIS; METABOLISM; ENVIRONMENTAL DEGRADATION; DECONTAMINATION;
D O I
10.1080/10426509208034494
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Some derivatives of 1,1'-thiobis(2-chloroethane) (sulphur mustard) have been synthesised for use as reference compounds in a wide range of studies embracing analysis, metabolism, environmental degradation and decontamination. Compounds include products formed by hydrolysis, substitution and elimination reactions and their oxidised sulphoxide and sulphone analogues. A comprehensive series of methylthio, methylsulphinyl and methylsulphonyl derivatives has been synthesised in support of metabolic studies.
引用
收藏
页码:31 / 47
页数:17
相关论文
共 32 条
[1]  
ALEXANDER JR, 1932, J CHEM SOC, P1913
[2]  
BALES SH, 1922, J CHEM SOC, P2137
[3]  
BARRETT GC, 1979, COMPREHENSIVE ORGANI, V3, P33
[4]  
BENNET GM, 1921, J CHEM SOC, P1860
[5]   THE CHEMISTRY OF 1,1'-THIOBIS(2-CHLOROETHANE) (SULFUR MUSTARD) .2. THE SYNTHESIS OF SOME CONJUGATES WITH CYSTEINE, N-ACETYLCYSTEINE AND N-ACETYLCYSTEINE METHYL-ESTER [J].
BLACK, RM ;
BREWSTER, K ;
CLARKE, RJ ;
HARRISON, JM .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1992, 71 (1-4) :49-58
[6]   BIOLOGICAL FATE OF SULFUR MUSTARD, 1,1'-THIOBIS(2-CHLOROETHANE) - ISOLATION AND IDENTIFICATION OF URINARY METABOLITES FOLLOWING INTRAPERITONEAL ADMINISTRATION TO RAT [J].
BLACK, RM ;
BREWSTER, K ;
CLARKE, RJ ;
HAMBROOK, JL ;
HARRISON, JM ;
HOWELLS, DJ .
XENOBIOTICA, 1992, 22 (04) :405-418
[7]   ANALYSIS OF 1,1'-SULPHONYLBIS[2-(METHYLSULPHINYL)ETHANE] AND 1-METHYLSULFINYL-2-[2-(METHYLTHIO)ETHYLSULPHONYL]ETHANE, METABOLITES OF SULFUR MUSTARD, IN URINE USING GAS-CHROMATOGRAPHY MASS-SPECTROMETRY [J].
BLACK, RM ;
CLARKE, RJ ;
READ, RW .
JOURNAL OF CHROMATOGRAPHY, 1991, 558 (02) :405-414
[8]   THE METHYL THIOETHERS DERIVED FROM 2 2'-DICHLORODIETHYL SULPHIDE AND ITS ANALOGUES .3. SYNTHETIC EXPERIMENTS [J].
BROWN, R ;
MOGGRIDGE, RCG .
JOURNAL OF THE CHEMICAL SOCIETY, 1946, (SEP) :816-819
[9]  
DAVIES JSH, 1931, J CHEM SOC, P2240
[10]   SOME DERIVATIVES OF ETHANE-1 - 2-DITHIOL AND 2-MERCAPTOETHYL SULPHOXIDES [J].
FORDMOORE, AH .
JOURNAL OF THE CHEMICAL SOCIETY, 1949, (SEP) :2126-2128