OPIATE WITHDRAWAL INCREASES GLUTAMATE AND ASPARTATE EFFLUX IN THE LOCUS-COERULEUS - AN IN-VIVO MICRODIALYSIS STUDY

被引：182

作者：

AGHAJANIAN, GK

KOGAN, JH

MOGHADDAM, B

机构：

[1] YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT 06508

[2] YALE UNIV,SCH MED,DEPT PHARMOCOL,NEW HAVEN,CT 06508

[3] YALE UNIV,SCH MED,DEPT CELLULAR & MOLEC PHYSIOL,NEW HAVEN,CT 06508

来源：

BRAIN RESEARCH | 1994年 / 636卷 / 01期

关键词：

ASPARTATE; EXCITATORY AMINO ACID; GLUTAMATE; LOCUS COERULEUS; MICRODIALYSIS; NALTREXONE; OPIATE WITHDRAWAL;

D O I：

10.1016/0006-8993(94)90186-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in the locus coeruleus. A withdrawal-induced increase in glutamate and aspartate efflux was found when the microdialysis probe was located in the core of the locus coeruleus; no increase was seen in adjacent regions.

引用

页码：126 / 130

页数：5

共 27 条

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TOLERANCE OF LOCUS COERULEUS NEURONS TO MORPHINE AND SUPPRESSION OF WITHDRAWAL RESPONSE BY CLONIDINE [J].