VARIABLE-ANGLE SCANNING FLUORESCENCE SPECTROMETRY FOR THE SIMULTANEOUS DETERMINATION OF 3 DIURETIC DRUGS

被引:26
作者
SANCHEZ, FG
GUTIERREZ, AF
BLANCO, CC
机构
[1] UNIV MALAGA,DEPT ANALYT CHEM,E-29071 MALAGA,SPAIN
[2] UNIV GRANADA,FAC SCI,DEPT ANALYT CHEM,E-18071 GRANADA,SPAIN
关键词
FLUOROMETRY; DIURETICS; PHARMACEUTICAL ANALYSIS;
D O I
10.1016/0003-2670(94)00689-J
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The applicability of variable-angle synchronous scanning (VASS) fluorescence spectroscopy has been demonstrated for the resolution of mixtures of three diuretics (furosemide, triamterene, piretamide) with closely overlapping fluorescence profiles. This technique permits linear or non-linear paths to be scanned at preselected angles through the excitation-emission matrix by scanning both monochromators at different speeds, in order to obtain the best variable-angle scanning spectra (highest signal values and interference-free bands). Such an approach has permitted the simultaneous determination of the three compounds at the mu g to ng ml(-1) level, with a relative standard deviation less than or equal to 5% (n = 10). When applied to commercial pharmaceutical dosage forms, recoveries of the original drug between 98-101% have been obtained.
引用
收藏
页码:313 / 321
页数:9
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