APPLICATION OF ENZYMATIC BAEYER-VILLIGER OXIDATIONS OF 2-SUBSTITUTED CYCLOALKANONES TO THE TOTAL SYNTHESIS OF (R)-(+)-LIPOIC ACID

被引：52

作者：

ADGER, B

BES, MT

GROGAN, G

MCCAGUE, R

PEDRAGOSAMOREAU, S

ROBERTS, SM

VILLA, R

WAN, PWH

WILLETTS, AJ

机构：

[1] UNIV EXETER, DEPT CHEM, EXETER EX4 4QD, DEVON, ENGLAND

[2] UNIV EXETER, DEPT BIOL SCI, EXETER EX4 4QG, DEVON, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 15期

关键词：

D O I：

10.1039/c39950001563

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxidation of ketones 1a-h using a monooxygenase from Pseudomonas putida NCIMB 10007 gave the lactones 2a-h in optically active form: lactone 2h was converted into (R)-(+)-lipoic acid 9.

引用

页码：1563 / 1564

页数：2

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