REGULATION OF CARBOHYDRATE-METABOLISM IN MOUSE-LIVER - EFFECT OF GLUCAGON ON GLUCONEOGENIC-GLYCOLYTIC FLUX IN ISOLATED PERFUSED LIVERS

被引：3

作者：

COOK, DE

SCHUSTER, SM

HEIDRICK, ML

FIENHOLD, MA

COOK, W

MARKIN, RS

机构：

[1] UNIV NEBRASKA,DEPT CHEM,LINCOLN,NE 68588

[2] UNIV NEBRASKA,SCH LIFE SCI,LINCOLN,NE 68588

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1979年 / 64卷 / 01期

关键词：

D O I：

10.1016/0305-0491(79)90180-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Glucagon stimulated gluconeogenesis from both [U-14C]lactate and [14C]xylitol in isolated perfused mouse liver. 2. 2. Addition of cyclic AMP also stimulated gluconeogenesis from [U-14C]lactate. 3. 3. Glucagon caused a rapid (2.5 min) 12-fold increase in hepatic cyclic AMP but not cyclic GMP concentration. 4. 4. Glucagon caused a rapid and stable decrease in hepatic fructose 1,6-diphosphatase activity measured in vitro. 5. 5. The results are interpreted to indicate that glucagon stimulates hepatic gluconeogenesis in mice via cyclic AMP by two different mechanisms: (a) increased substrate uptake (i.e. utilization) and (b) increased gluconeogenic efficiency (i.e. inhibition of alternate substrate fates). © 1979.

引用

页码：33 / 39

页数：7

共 36 条

[1] GLUCOSE SYNTHESIS BY ISOLATED GUINEA-PIG HEPATOCYTES - EFFECT OF CYCLIC-AMP AND DIBUTYRYL CYCLIC-AMP [J].