(A)BC EXCINUCLEASE - THE ESCHERICHIA-COLI NUCLEOTIDE EXCISION REPAIR ENZYME

被引：92

作者：

LIN, JJ ^{[1
]}

SANCAR, A ^{[1
]}

机构：

[1] UNIV N CAROLINA, SCH MED, DEPT BIOCHEM & BIOPHYS, CHAPEL HILL, NC 27599 USA

来源：

MOLECULAR MICROBIOLOGY | 1992年 / 6卷 / 16期

关键词：

D O I：

10.1111/j.1365-2958.1992.tb01398.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleotide excision repair is the major pathway for removing damage from DNA. (A)BC excinuclease is the nuclease activity which initiates nucleotide excision repair in Escherichia coli. In this review, we focus on current understanding of the structure-function of the enzyme and the reaction mechanism of the repair pathway. In addition, recent biochemical studies on preferential repair of actively transcribed genes in E. coli are summarized.

引用

页码：2219 / 2224

页数：6

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