PHAGOCYTOSIS AND ALGICIDAL ACTIVITY OF HUMAN POLYMORPHONUCLEAR NEUTROPHILS AGAINST PROTOTHECA-WICKERHAMII

被引：42

作者：

PHAIR, JP

WILLIAMS, JE

BASSARIS, HP

ZEISS, CR

MORLOCK, BA

机构：

[1] NORTHWESTERN UNIV, SCH MED, DEPT MED, CHICAGO, IL 60611 USA

[2] NORTHWESTERN UNIV, SCH MED, DEPT PATHOL, CHICAGO, IL 60611 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1981年 / 144卷 / 01期

关键词：

D O I：

10.1093/infdis/144.1.72

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protothecosis is an uncommon infection due to P. wickerhamii. Recently, a patient with progressive cutaneous protothecosis and an apparent defect in the ability of her polymorphonuclear neutrophils (PMN) to kill P. wickerhamii was successfully treated. The role of PMN and serum opsonins in host defense against tissue invasion by this organism was evaluated. Human PMN ingest and kill P. wickerhamii. Ultrastructural studies revealed digestion of the organisms by PMN 60 min after ingestion. Optimal phagocytosis and killing of P. wickerhamii by PMN required the presence of both specific IgG antibody and heat-labile opsonins.

引用

页码：72 / 76

页数：5

共 16 条

[1] CHANDLER FW, 1978, ARCH PATHOL LAB MED, V102, P353
[2] COX GE, 1974, LANCET, V2, P379
[3] GOLDSTEIN IM, 1976, J IMMUNOL, V117, P1282
[4] PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY
GREENWOOD, FC
HUNTER, WM
[J]. BIOCHEMICAL JOURNAL, 1963, 89 (01) : 114 - &
[5] Grocott RG, 1979, LAB MED, V10, P89
[6] KAPLAN W, 1979, 4TH P INT C MYC, P218
[7] KARNOVSKY MJ, 1965, J CELL BIOL, V27, pA137
[8] Mancini G, 1965, Immunochemistry, V2, P235, DOI 10.1016/0019-2791(65)90004-2
[9] CUTANEOUS PROTOTHECOSIS - SUCCESSFUL TREATMENT WITH AMPHOTERICIN-B
MAYHALL, CG
MILLER, CW
EISEN, AZ
KOBAYASHI, GS
MEDOFF, G
[J]. ARCHIVES OF DERMATOLOGY, 1976, 112 (12) : 1749 - 1752
[10] RAPID IDENTIFICATION OF PROTOTHECA SPECIES BY THE API-20C SYSTEM
PADHYE, AA
BAKER, JG
DAMATO, RF
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1979, 10 (04) : 579 - 582

← 1 2 →