FGF-2 - APICAL ECTODERMAL RIDGE GROWTH SIGNAL FOR CHICK LIMB DEVELOPMENT

被引：417

作者：

FALLON, JF

LOPEZ, A

ROS, MA

SAVAGE, MP

OLWIN, BB

SIMANDL, BK

机构：

[1] UNIV WISCONSIN,NEUROSCI TRAINING PROGRAM,MADISON,WI 53706

[2] UNIV CANTABRIA,DEPT ANAT & BIOL CELULAR,E-39011 SANTANDER,SPAIN

[3] PURDUE UNIV,DEPT BIOCHEM,W LAFAYETTE,IN 47907

来源：

SCIENCE | 1994年 / 264卷 / 5155期

关键词：

D O I：

10.1126/science.7908145

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The apical ectodermal ridge permits growth and elongation of amniote limb buds; removal causes rapid changes in mesodermal gene expression, patterned cell death, and truncation of the limb. Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development. A bioassay for FGFs demonstrated that FGF-2 was the only detectable FGF in chick limb bud extracts. By distribution and bioactivity, FGF-2 is the prime candidate for the chick limb bud apical ridge growth signal.

引用

页码：104 / 107

页数：4

共 30 条

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