ASSIGNMENT OF THE CHROMOGRANIN-A (CHGA) LOCUS TO HOMOLOGOUS REGIONS ON MOUSE CHROMOSOME-12 AND RAT CHROMOSOME-6

被引：18

作者：

SIMONCHAZOTTES, D

WU, HJ

PARMER, RJ

ROZANSKY, DJ

SZPIRER, J

LEVAN, G

KURTZ, TW

SZPIRER, C

GUENET, JL

OCONNOR, DT

机构：

[1] UNIV CALIF SAN DIEGO,DEPT MED,DIV NEPHROL HYPERTENS 9111H,3350 LA JOLLA VILLAGE DR,SAN DIEGO,CA 92161

[2] UNIV CALIF SAN DIEGO,CTR MOLEC GENET,SAN DIEGO,CA 92161

[3] DEPT VET AFFAIRS MED CTR,SAN DIEGO,CA

[4] UNIV LIBRE BRUXELLES,B-1640 RHODE ST GENESE,BELGIUM

[5] INST PASTEUR,F-75724 PARIS 15,FRANCE

[6] GOTHENBURG UNIV,DEPT GENET,S-41124 GOTHENBURG,SWEDEN

[7] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143

来源：

GENOMICS | 1993年 / 17卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1316

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chromogranin A is an acidic protein, stored and released with catecholamines, and is overexpressed in genetic hypertension. In the human genome, its locus has previously been positioned on the long arm of Chromosome 14 in the 14q32 region. As a first step toward evaluating its potential linkage with hereditary hypertension, we determined its chromosomal position in mouse and rat. Chromogranin A was present as a single-copy gene in both mouse and rat. Analysis of the allele distribution in an interspecific mouse backcross by single-strand conformation polymorphism positioned the chromogranin A locus on Chromosome 12, between Igh-C and D12Pas1. Evaluation of a rat/mouse somatic cell hybrid panel indicated that, chromogranin A is on rat Chromosome 6. In each case (mouse, rat, and human), chromogranin A is in a conserved region with nearby markers including the immunoglobulin heavy chain locus. © 1993 Academic Press. All rights reserved.

引用

页码：252 / 255

页数：4

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