LOCALIZATION OF ABSORBERS IN SCATTERING MEDIA BY USE OF FREQUENCY-DOMAIN MEASUREMENTS OF TIME-DEPENDENT PHOTON MIGRATION

被引：48

作者：

SEVICK, EM ^{[1
]}

FRISOLI, JK ^{[1
]}

BURCH, CL ^{[1
]}

LAKOWICZ, JR ^{[1
]}

机构：

[1] UNIV MARYLAND, SCH MED, CTR FLUORESCENCE SPECT, DEPT BIOL CHEM, BALTIMORE, MD 21201 USA

来源：

APPLIED OPTICS | 1994年 / 33卷 / 16期

关键词：

BIOMEDICAL OPTICAL IMAGING; PHOTON-MIGRATION IMAGING; FREQUENCY-DOMAIN IMAGING;

D O I：

10.1364/AO.33.003562

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Frequency-domain studies of time-dependent light propagation in tissuelike phantoms that contain optical heterogeneities are described. Specifically the phase shift and amplitude modulation of reemergent light were measured when illuminated by an amplitude-modulated light source. Changes in the phase angle and the extent of modulation revealed the presence of a light-absorbing object. Furthermore the magnitude and direction of these changes were sensitive to the absorber depth and the light modulation frequency in a manner that could be used to infer the location of the heterogeneity. These data suggest the feasibility of optical imaging by frequency-domain methods.

引用

页码：3562 / 3571

页数：10

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