V-BETA GENE REPERTOIRES IN T-CELLS EXPANDED IN LOCAL SELF-HEALING AND LETHAL SYSTEMIC MURINE CUTANEOUS LEISHMANIASIS

被引：9

作者：

LOHOFF, M ^{[1
]}

STEINERT, M ^{[1
]}

WEISS, A ^{[1
]}

ROLLINGHOFF, M ^{[1
]}

BALDERAS, RS ^{[1
]}

THEOFILOPOULOS, AN ^{[1
]}

机构：

[1] SCRIPPS RES INST, LA JOLLA, CA USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 02期

关键词：

MURINE; LEISHMANIASIS; T CELL RECEPTOR; CD4;

D O I：

10.1002/eji.1830240236

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inbred mice infected with Leishmania major promastigotes display two different courses of leishmaniasis: resistant strains develop self-healing local sores, while susceptible strains show progressive systemic disease with lethal outcome. Resistance predominantly correlates with the production of T helper type 1 (TH1) lymphokines and susceptibility with production of TH2-type lymphokines. Here, we analyzed whether this TH phenotype difference correlates with expression of particular T cell receptor V beta chains. Our results show that T cells expand strongly during infection in all groups of mice and invariantly express the same V beta gene families as prior to infection. Our data indicate that TH1 and TH2 cells use similar V beta gene families, and argue against the engagement of a restricted set of V beta by dominant determinants associated with L. major:

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页码：492 / 495

页数：4

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