TIAGABINE

被引：40

作者：

MENGEL, H

机构：

[1] Novo Nordisk A/S, Måløv

来源：

EPILEPSIA | 1994年 / 35卷

关键词：

ANTICONVULSANTS; TIAGABINE; DRUG TOXICITY; DRUG SCREENING; PRECLINICAL DRUG EVALUATION; CONTROLLED CLINICAL TRIALS; PHARMACOKINETICS; DRUG INTERACTION;

D O I：

10.1111/j.1528-1157.1994.tb05976.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tiagabine (TGB), a specific gamma-aminobutyric acid (GABA)-uptake inhibitor, is a potential new antiepileptic drug with a novel mechanism of action. In animals of epilepsy as well as in a placebo-controlled trial in patients with complex partial seizures, TGB showed significant anticonvulsant effects. TGB was well tolerated by most patients.

引用

页码：S81 / S84

页数：4

共 9 条

[1] (R)-N-[4,4-BIS(3-METHYL-2-THIENYL)BUT-3-EN-1-YL]NIPECOTIC ACID BINDS WITH HIGH-AFFINITY TO THE BRAIN GAMMA-AMINOBUTYRIC ACID UPTAKE CARRIER [J].