FREEZE-DRIED PREPARATIONS OF KETOPROFEN AND HEPTAKIS-(2,6-O-DIMETHYL)-BETA-CYCLODEXTRIN

被引：19

作者：

FUNK, O

SCHWABE, L

FROMMING, KH

机构：

[1] Institut fur Pharmazie der Freien, Universitat Berlin, 12169, Berlin

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1994年 / 20卷 / 12期

关键词：

D O I：

10.3109/03639049409049330

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The purpose of this study was to examine the inclusion formation in freeze-dried preparations of ketoprofen and heptakis-(2,6-0-dimethyl)-beta-cyclodextrin. The products obtained were amorphous mixtures of the two components. X-ray diffractography, differential scanning calorimetry, C-13-CPMAS-NMR spectroscopy and thermofractography did not give any proof of an inclusion of ketoprofen in the cyclodextrin cavity.

引用

页码：1957 / 1969

页数：13

共 8 条

[1]

AUTERHOFF H, 1985, IDENTIFIZIERUNG ARZN, P76

[2] INFLUENCE OF METHOD OF PREPARATION ON INCLUSION COMPLEXES OF NAPROXEN WITH DIFFERENT CYCLODEXTRINS [J].