NATURAL-KILLER-CELLS CARRY THE GERM-LINE CONFIGURATION OF THE T-CELL RECEPTOR DELTA-CHAIN GENE AND HETEROGENEOUSLY EXPRESS 6 DISTINCT DELTA-TRANSCRIPTS

被引：7

作者：

CARE, A

PELICCI, PG

MECCIA, E

FAGIOLI, M

TESTA, U

CICCONE, E

MORETTA, A

MORETTA, L

PESCHLE, C

机构：

[1] UNIV GENEVA, IST NAZL RIC CANC, CH-1211 GENEVA 4, SWITZERLAND

[2] UNIV PERUGIA, MONTELUCE POLICLIN, IST CLIN MED, I-06100 PERUGIA, ITALY

[3] UNIV GENEVA, IST ONCOL, CH-1211 GENEVA 4, SWITZERLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 04期

关键词：

D O I：

10.1002/eji.1830200434

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Investigations on T cell receptor δ chain (TcR δ) gene expression in freshly isolated normal large granular lymphocytes, natural killer (NK) cell clones and NK bulk cultures revealed six Tδ transcripts (3.5, 3.1, 2.2, 2.0, 1.5 and 1.3 kb) which varied in number and relative abundance in the different samples. None of the six known Tδ variable regions was expressed and the Tδ locus was retained in its germ‐line configuration. The origin and significance of these NK‐associated Tδ transcripts are discussed. Copyright © 1990 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：939 / 942

页数：4

共 24 条

[1] BIASSONI R, 1988, J IMMUNOL, V140, P1685
[2] 2 SUBSETS OF HUMAN LYMPHOCYTES-T EXPRESSING GAMMA-ANTIGEN DELTA-ANTIGEN RECEPTOR ARE IDENTIFIABLE BY MONOCLONAL-ANTIBODIES DIRECTED TO 2 DISTINCT MOLECULAR-FORMS OF THE RECEPTOR
BOTTINO, C
TAMBUSSI, G
FERRINI, S
CICCONE, E
VARESE, P
MINGARI, MC
MORETTA, L
MORETTA, A
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (02) : 491 - 505
[3] SPECIFIC LYSIS OF ALLOGENEIC CELLS AFTER ACTIVATION OF CD3- LYMPHOCYTES IN MIXED LYMPHOCYTE CULTURE
CICCONE, E
VIALE, O
PENDE, D
MALNATI, M
BIASSONI, R
MELIOLI, G
MORETTA, A
LONG, EO
MORETTA, L
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (06) : 2403 - 2408
[4] FALINI B, IN PRESS BLOOD
[5] CHARACTERIZATION OF CD3+, CD4-, CD8- CLONES EXPRESSING THE PUTATIVE T-CELL RECEPTOR GAMMA-GENE PRODUCT - ANALYSIS OF THE ACTIVATION PATHWAYS LEADING TO INTERLEUKIN-2 PRODUCTION AND TRIGGERING OF THE LYTIC MACHINERY
FERRINI, S
BOTTINO, C
BIASSONI, R
POGGI, A
SEKALY, RP
MORETTA, L
MORETTA, A
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (01) : 277 - 282
[6] FITZGERALDBOCAR.P, 1988, IMMUNOL TODAY, V9, P292
[7] T-CELL RECEPTOR GENE REARRANGEMENTS AS MARKERS OF LINEAGE AND CLONALITY IN T-CELL NEOPLASMS
FLUG, F
PELICCI, PG
BONETTI, F
KNOWLES, DM
DALLAFAVERA, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (10) : 3460 - 3464
[8] FOA R, 1986, BLOOD, V67, P247
[9] HUMAN-T CELLS EXPRESSING THE GAMMA-DELTA T-CELL RECEPTOR (TCR-1) - C-GAMMA-1-ENCODED AND C-GAMMA-2-ENCODED FORMS OF THE RECEPTOR CORRELATE WITH DISTINCTIVE MORPHOLOGY, CYTOSKELETAL ORGANIZATION, AND GROWTH-CHARACTERISTICS
GROSSI, CE
CICCONE, E
MIGONE, N
BOTTINO, C
ZARCONE, D
MINGARI, MC
FERRINI, S
TAMBUSSI, G
VIALE, O
CASORATI, G
MILLO, R
MORETTA, L
MORETTA, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (05) : 1619 - 1623
[10] NATURAL-KILLER CELLS - THEIR ROLE IN DEFENSES AGAINST DISEASE
HERBERMAN, RB
ORTALDO, JR
[J]. SCIENCE, 1981, 214 (4516) : 24 - 30

← 1 2 3 →