THE COMPLETE AMINO-ACID-SEQUENCE OF A POSTSYNAPTIC NEUROTOXIN ISOLATED FROM THE VENOM OF THE AUSTRALIAN DEATH ADDER SNAKE ACANTHOPHIS-ANTARCTICUS

被引：27

作者：

SHEUMACK, DD

SPENCE, I

TYLER, MI

HOWDEN, MEH

机构：

[1] DEAKIN UNIV,DEPT BIOL SCI,GEELONG,VIC 3217,AUSTRALIA

[2] MACQUARIE UNIV,SCH CHEM,N RYDE,NSW 2109,AUSTRALIA

[3] UNIV SYDNEY,DEPT PHARMACOL,SYDNEY,NSW 2006,AUSTRALIA

[4] CSIRO,DEAKIN RES LTD,DIV FOOD PROC,N RYDE,NSW 2113,AUSTRALIA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1990年 / 95卷 / 01期

关键词：

D O I：

10.1016/0305-0491(90)90246-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. A lethal neurotoxin (acanthophin d) was isolated from the venom of the Australian death adder snake Acanthophis antarcticus. 2. 2. Acanthophin d consisted of a single polypeptide chain of 74 amino acid residues cross-linked by five disulphide bridges. 3. 3. The results of neurophysiological experiments on murine phrenic nerve hemi-diaphragm preparations were consistent with irreversible post-synaptic blockage of neuromuscular transmission by acanthophin d. © 1989.

引用

页码：45 / 50

页数：6

共 26 条

[1]

BAHL OP, 1965, J BIOL CHEM, V240, P3585

[2] A NEUROTOXIN OF NOVEL STRUCTURAL TYPE FROM THE VENOM OF THE AUSTRALIAN COMMON BROWN SNAKE [J].