PYRUVATE SPARING BY BUTYRATE AND PROPIONATE IN PROLIFERATING COLONIC EPITHELIUM

被引:12
作者
BUTLER, RN
STAFFORD, I
TRIANTAFILLOS, E
ODEE, CD
JARRETT, IG
FETTMAN, MJ
ROBERTSTHOMSON, IC
机构
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1990年 / 97卷 / 02期
关键词
D O I
10.1016/0305-0491(90)90290-A
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1. 1. The effects of fasting and fasting followed by refeeding on the relative activities of the pyruvate dehydrogenase (PDH) complex and the tricarboxylic acid (TCA) cycle in isolated rat colonocytes were estimated by the rate of production of 14CO2 from [1-14C] pyruvate and [3-14C] pyruvate, respectively. 2. 2. Decarboxylation of pyruvate by the PDH complex exceeded that by the TCA cycle in both fasted and fasted/refed colonocytes, was higher in distal than in proximal colon, and was stimulated by refeeding following a fast. 3. 3. Oxidation of pyruvate by both the PDH complex and the TCA cycle was inhibited by butyrate. 4. 4. Propionate alone had no effect, but synergized with butyrate to further reduce pyruvate decarboxylation by the TCA cycle. 5. 5. Preferential utilization of butyrate by proliferating colonic epithelial cells is postulated to maximize the energy yield and spare pyruvate and its precursors for alternative synthetic roles necessary for active cell division. © 1990.
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页码:333 / 337
页数:5
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