HISTOLOGIC FEATURES OF HUMAN ORBICULARIS OCULI TREATED WITH BOTULINUM-A TOXIN

被引：50

作者：

HARRIS, CP

ALDERSON, K

NEBEKER, J

HOLDS, JB

ANDERSON, RL

机构：

[1] UNIV UTAH,SCH MED,DEPT NEUROL,SALT LAKE CITY,UT 84112

[2] UNIV UTAH,SCH MED,DEPT OPHTHALMOL,DIV OCULOPLAST SURG,SALT LAKE CITY,UT 84112

[3] VET ADM MED CTR,DIV NEUROL,SALT LAKE CITY,UT 84148

[4] UNIV TEXAS,MED BRANCH,DEPT OPHTHALMOL,GALVESTON,TX 77550

来源：

ARCHIVES OF OPHTHALMOLOGY | 1991年 / 109卷 / 03期

关键词：

D O I：

10.1001/archopht.1991.01080030095046

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

To evaluate muscle histologic features in humans following therapeutic botulinum toxin injections, we studied orbicularis oculi from 11 patients with blepharospasm; nine had previously received botulinum toxin injections and two had not. All muscles had comparable variability in muscle fiber diameter, with no necrosis, inflammation, denervation, or consistent alterations in muscle fiber internal architecture. Botulinum toxin produces no persistent histologic changes in human muscle fibers.

引用

页码：393 / 395

页数：3

共 12 条

[1]

BLITZER A, 1988, LARYNGOSCOPE, V98, P193

[2] BOTULINUM TOXIN FOR RELIEF OF BILATERAL ABDUCTOR PARALYSIS OF THE LARYNX - HISTOLOGIC-STUDY IN AN ANIMAL-MODEL [J].