PYRIDINIUM AZOLATE BETAINES AND THEIR DERIVATIVES - A NEW CLASS OF ANTIPROTOZOAL AGENTS

被引：22

作者：

ALCALDE, E

DINARES, I

ELGUERO, J

FRIGOLA, J

OSUNA, A

CASTANYS, S

机构：

[1] CSIC,INST QUIM MED,E-28006 MADRID,SPAIN

[2] LAB DR ESTEVE SA,E-08026 BARCELONA,SPAIN

[3] UNIV GRANADA,FAC FARM,DEPT PARASITOL,E-18001 GRANADA,SPAIN

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 04期

关键词：

anti-leishmanial activity; N-azolylpyridinium salts; pyridinium azolate mesomeric betaines;

D O I：

10.1016/0223-5234(90)90114-I

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-azolylpyridinium salts 1 and several betaines of pyridinium azolate 2 have been synthetized in order to study their in vitro antiprotozoal activity. A careful 1H and 13C-NMR study has been carried out in order to characterize the different compounds. A significant growth inhibition of Trypanosoma cruzi and especially Leishmania donovani was observed with the N-benzimidazolyl-pyridinium derivatives. When tested in vivo against Leishmania donovani, compounds 9 and 40 have had a much greater reducing effect in the parasite than that of the reference drug (glucantime). © 1990.

引用

页码：309 / 319

页数：11

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