ESTIMATION OF RELATIVE POTENCY WITH SEQUENTIAL DILUTION ERRORS IN RADIOIMMUNOASSAY

被引：17

作者：

RACINEPOON, A

WEIHS, C

SMITH, AFM

机构：

[1] CIBA GEIGY AG,MATH APPLICAT,CH-4002 BASEL,SWITZERLAND

[2] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT MATH,LONDON SW7 2BZ,ENGLAND

来源：

BIOMETRICS | 1991年 / 47卷 / 04期

关键词：

BAYESIAN METHODS; LOGISTIC LOGARITHM CURVE; MAXIMUM LIKELIHOOD ESTIMATION; MEASUREMENT ERROR MODEL; RADIOIMMUNOASSAY; RELATIVE POTENCY; SEQUENTIAL DILUTION;

D O I：

10.2307/2532382

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sequential dilution is a very common procedure in radioimmunoassay, in which the dilution error will be accumulated from the highest to the lowest concentration. A simulated example in relative potency determination is used to demonstrate the potentially wrong conclusion that can be drawn, when the dilution error is not properly included in the model. A Bayesian method is used and an alternative approximation via maximum likelihood is proposed. An alternative experimental design is recommended to increase the precision of the inference.

引用

页码：1235 / 1246

页数：12

共 12 条

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