GUANIDINO COMPOUNDS IN SERUM, URINE, LIVER, KIDNEY, AND BRAIN OF MAN AND SOME UREOTELIC ANIMALS

被引：119

作者：

MARESCAU, B ^{[1
]}

DESHMUKH, DR ^{[1
]}

KOCKX, M ^{[1
]}

POSSEMIERS, I ^{[1
]}

QURESHI, IA ^{[1
]}

WIECHERT, P ^{[1
]}

DEDEYN, PP ^{[1
]}

机构：

[1] GEN HOSP MIDDELHEIM, DEPT NEUROL, ANTWERP, BELGIUM

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1992年 / 41卷 / 05期

关键词：

D O I：

10.1016/0026-0495(92)90213-T

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Guanidino compound levels were quantitatively determined in serum, urine, liver, kidney, and brain of man and of some ureotelic animals. The guanidino compounds were separated over a cation exchange resin, using sodium citrate buffers, and detected with the fluorescence ninhydrin method. Species-specific differences in the levels of some guanidino compounds in the studied ureotelic animals are shown. α-Keto-δ-guanidinovaleric acid is a naturally occurring guanidino compound in ureotelic animals, and is not restricted to the pathobiochemistry to hyperargininemic patients. The fasting serum levels observed in beagles are the same as those found in hyperargininemic patients. In serum, liver, and kidney, the homoarginine, β-guanidinopropionic acid, and γ-guanidinobutyric acid levels are the highest in rats. The last two compounds have the highest levels of the studied guanidino compounds, with the exception of creatine, in kidney. Specific high levels of γ-guanidinobutyric acid and argininic acid are found in brain of rabbits. © 1992.

引用

页码：526 / 532

页数：7

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