PROGESTERONE REGULATION OF ESTROGEN-RECEPTOR IN THE RAT UTERUS - A PRIMARY INHIBITORY INFLUENCE ON THE NUCLEAR FRACTION

被引:65
作者
OKULICZ, WC [1 ]
EVANS, RW [1 ]
LEAVITT, WW [1 ]
机构
[1] WORCESTER FDN EXPTL BIOL, SHREWSBURY, MA 01545 USA
关键词
D O I
10.1016/0039-128X(81)90047-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The short-term effects of progesterone action of estrogen receptor (Re) levels in the rat uterus were determined. Ovariectomized, adrenalectomized rats were maintained on s.c. Silastic implants containing crystalline estradiol. Progesterone treatment with serum estradiol maintenance caused a rapid decrease (within 4 h) of total Re, attributable to loss of nuclear Re without a significant change in cytosol Re levels. Removal of estradiol implants resulted in an increase in total Re and cytosol Re at all time periods studied without a significant decrease in nuclear Re until 8 h. Combined estradiol withdrawal and progesterone treatment resulted in lower total Re levels and a more rapid decrease in nuclear Re than with estradiol withdrawal alone. Progesterone rapidly and selectively decreases nuclear Re levels in rat uterus and this process is not dependent on cytosol Re or serum estradiol levels.
引用
收藏
页码:463 / 470
页数:8
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