MOLECULAR-CLONING OF THE CDNA-ENCODING A RECEPTOR TYROSINE KINASE-RELATED MOLECULE WITH A CATALYTIC REGION HOMOLOGOUS TO C-MET

被引：25

作者：

PAUL, SR

MERBERG, D

FINNERTY, H

MORRIS, GE

MORRIS, JC

JONES, SS

TURNER, KJ

WOOD, CR

机构：

[1] GENET INST, CAMBRIDGE, MA USA

[2] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, BOSTON, MA 02115 USA

[3] HARVARD UNIV, CHILDRENS HOSP, SCH MED, BOSTON, MA 02115 USA

来源：

INTERNATIONAL JOURNAL OF CELL CLONING | 1992年 / 10卷 / 05期

关键词：

TYROSINE KINASE; MOLECULAR CLONING; POLYMERASE CHAIN REACTION;

D O I：

10.1002/stem.5530100509

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Receptor tyrosine kinases mediate a range of growth and differentiation processes in multiple biological systems. In this work, we report the identification of a novel tyrosine kinase-related molecule, nyk-r, and the molecular cloning of its complete cDNA. Its extracellular domain bears no apparent homology with other receptor families, but its intracellular kinase-related region has considerable similarity with members of the insulin-receptor family such as c-met and trk B. Also, the nyk-r gene is expressed in a wide range of tissues and cell lines.

引用

页码：309 / 314

页数：6

共 37 条

[1] PRODUCTION OF HYBRIDOMA GROWTH-FACTOR BY HUMAN-MONOCYTES [J].