ANALYSIS OF THE 11P13 WILMS-TUMOR SUPPRESSOR GENE (WT1) IN OVARIAN-TUMORS

被引：77

作者：

BRUENING, W

GROS, P

SATO, T

STANIMIR, J

NAKAMURA, Y

HOUSMAN, D

PELLETIER, J

机构：

[1] MCGILL UNIV,DEPT BIOCHEM,ROOM 902,3655 DROMMOND ST,MONTREAL H3G 1Y6,QUEBEC,CANADA

[2] JAPANESE FDN CANC RES,DEPT BIOCHEM,TOSHIMA KU,TOKYO 170,JAPAN

[3] ROYAL VICTORIA HOSP,DEPT OBSTET & GYNECOL,MONTREAL H3A 1A1,QUEBEC,CANADA

[4] MCGILL UNIV,MCGILL CANC CTR,MONTREAL H3G 1Y6,QUEBEC,CANADA

[5] MIT,CTR CANC RES,CAMBRIDGE,MA 02139

来源：

CANCER INVESTIGATION | 1993年 / 11卷 / 04期

关键词：

D O I：

10.3109/07357909309018871

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have examined the status of the Wilms' tumor suppressor gene (WT1), residing at chromosome 11 band p13, in a total of 40 cancers of the female reproductive tract. Northern blot analysis revealed that the WT1 gene is expressed in a large percentage of ovarian tumors (75%) analyzed. Single-strand conformation polymorphism analysis was performed on all the tumors in this study in an attempt to detect mutations within the WT1 gene. Only silent mutations were detected within intron 7 of WT1 using this method. Loss of heterozygosity studies were performed at the WT1 locus in several ovarian tumors and revealed that in the informative cases, heterozygosity was retained.

引用

页码：393 / 399

页数：7

共 21 条

[1]

AUFFRAY C, 1980, EUR J BIOCHEM, V107, P303

[2] 2ND MALIGNANT NEOPLASMS IN SURVIVORS OF WILMS TUMOR - A REPORT FROM THE NATIONAL WILMS TUMOR STUDY [J].