THE LATENT PERIOD OF MULTIPLE-SCLEROSIS - A CRITICAL-REVIEW

被引：38

作者：

WOLFSON, C

WOLFSON, DB

机构：

[1] Departments of Epidemiology and Biostatistics, Medicine, and Neurology and Neurosurgery, McGill University, Montreal, QC

[2] Department of Mathematics and Statistics, McGill University, Montreal, QC

来源：

EPIDEMIOLOGY | 1993年 / 4卷 / 05期

关键词：

MULTIPLE SCLEROSIS; LATENT PERIOD; MIGRANT STUDIES; CLUSTER STUDIES;

D O I：

10.1097/00001648-199309000-00013

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

It is a widely held belief that multiple sclerosis is a disease with a long latent period that is preceded by heightened susceptibility before adolescence. There has, however, been little research focused on either the estimation of the latent period or determination of the susceptibility period. In this article, we present a critical assessment of the relevant literature on migrant studies, cluster studies, the Faroe Islands ''epidemic,'' a sibling study, and novel statistical approaches as they pertain to the pre-onset natural history of multiple sclerosis. We also discuss the roles of the latent and susceptibility periods in the design, analysis, and interpretation of epidemiologic studies.

引用

页码：464 / 470

页数：7

共 54 条

[1] Acheson E.D., The Epidemiology of Multiple Sclerosis: The Pattern of the Disease, McAlpine’s Multiple Sclerosis, (1985)
[2] Wynn D.R., Rodriguez M., O'Fallon W.M., Kurland L.T., Update on the epidemiology of multiple sclerosis, Mayo Clin Proc, 64, pp. 808-817, (1989)
[3] Kurtzke J.F., Epidemiologic contributions to multiple sclerosis: An overview, Neurology, 30, pp. 61-79, (1980)
[4] Kurtzke J.F., A reassessment of the distribution of multiple sclerosis. Part One, Acta Neurol Scand, 51, pp. 110-136, (1975)
[5] Kurtzke J.F., A reassessment of the distribution of multiple sclerosis. Part Two, Acta Neurol Scand, 51, pp. 137-157, (1975)
[6] Rothman K.J., Induction and latent periods, Am J Epidemiol, 114, pp. 253-259, (1981)
[7] Kurtzke J.F., On the time of onset in multiple sclerosis, Acta Neurol Scand, 41, pp. 140-158, (1965)
[8] Detels R., Case-control studies of multiple sclerosis, Neuroepidemiology, 1, pp. 115-123, (1982)
[9] Kleinbaum D.G., Kupper L.L., Morgenstern H., Epidemiologyresearch: Principles and Quantitative Methods., (1982)
[10] Greenland S., Robins J.M., Confounding and misclassification, Am J Epidemiol, 122, pp. 495-506, (1985)

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