EFFECTS OF LEUKOTRIENE SYNTHESIS INHIBITION ON ACUTE LIVER-DAMAGE INDUCED BY CARBON-TETRACHLORIDE

Administration of the leukotriene synthesis inhibitors nordihydroguaiaretic acid (NDHGA, 30 mg/kg), caffeic acid (20 mg/kg) or nafazatrom (100 mg/kg) and of the phosphodiesterase inhibitor and free radical trapper dipyridamole (10 mg/kg) prevented the alterations in enzyme activity displayed by acute CCl4 administration. The effect was less evident in preventing hepatic glycogen depletion or lipid peroxidation. A synergistic protective effect between dipyridamole and NDHGA or caffeic acid was observed. In conclusion, the present results show that acute hepatic damage induced by CCl4 can be partially prevented by leukotriene synthesis inhibitors and the protection is enhanced with the simultaneous use of phosphodiesterase inhibitors.