SYNTHESIS OF CARBOHYDRATE PHOSTONES AS POTENTIAL GLYCOMIMETICS

被引：35

作者：

HANESSIAN, S ^{[1
]}

GALEOTTI, N ^{[1
]}

ROSEN, P ^{[1
]}

OLIVA, G ^{[1
]}

BABU, S ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE INC,RES LABS,NUTLEY,NJ 07110

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(01)80591-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of stereoisomeric monosaccharide delta-phostones (cyclic phosphonate esters) were prepared and their structures were confirmed by single crystal X-ray analysis. Esterification of the D-gluco phostonic acid with appropriate sugar alcohols gave the first 1 --> 6 and 1 --> 4 disaccharide glycomimetics with phosphorus at the anomeric carbon of the non-reducing unit. Their structures and configuration at phosphorus were established by X-ray analysis.

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页码：2763 / 2768

页数：6

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