IMMUNOPHENOTYPING OF CHILDHOOD ASTROCYTOMAS WITH A LIBRARY OF MONOCLONAL-ANTIBODIES

被引:69
作者
BODEY, B
ZELTZER, PM
SALDIVAR, V
KEMSHEAD, J
机构
[1] CHILDRENS HOSP, DEPT PEDIAT, DIV HEMATOL ONCOL, 4650 SUNSET BLVD, LOS ANGELES, CA 90054 USA
[2] UNIV SO CALIF, LOS ANGELES, CA 90089 USA
[3] UNIV TEXAS, HLTH SCI CTR, SAN ANTONIO, TX 78284 USA
[4] INST CHILD HLTH, IMPERIAL CANC RES FUND LABS, ONCOL LAB, LONDON WC1N 1EH, ENGLAND
关键词
D O I
10.1002/ijc.2910450617
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Immunophenotype (IP) analysis of 14 childhood glial tumors was performed with a library of 16 monoclonal antibodies (MAbs) using biotin‐streptavidin‐alkaline phosphatase immunohistochemical detection technique. Presence of glial or neuronal differentiated cells within the tumors was evaluated with MAbs against cell‐lineage‐specific markers: high‐, medium‐ and low‐molecular‐weight neurofilament protein (NFP) and glial fibrillary acidic protein (GFAP). Intense expression of GFAP was demonstrated in 14/14 astrocytomas. The three NFs were detected in 10–50% of the cells in 6/14 cases. The pan‐neuro‐ectodermal antigen defined by MAb UJ 13/A was present in 7/14 astrocytomas on more than 10% of the cells. Thy‐1 was expressed in 14/14 tumors on more than 50% of their cells. The GQ ganglioside antigen detected by MAB A2B5, was found in 12/14 tumors. Shared antigens exist among morphologically benign and malignant glial tumor cells and leukocytes detectable with the following four MAbs: Thy‐1, Pl 153/3, UJ 308 and anti‐HLe, common leukocyte antigen (CLA). CLA‐expressing cells were demonstrated in 8/12 astrocytomas, and in 4/12 cases more than 90% of the cells were positive. We have shown that cells within childhood astrocytomas can express neuronal IP. The most common expressed phenotype for glial tumors was: GFAP+, Thy‐1+, A2B5+, UJ 167.11+, UJ 223.8+, NF (H,M)+, UJ 13/A+, UJ 127.11−, and NF (L)−. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:1079 / 1087
页数:9
相关论文
共 56 条
[1]   BIOLOGICAL CHARACTERIZATION AND CLINICAL-APPLICATIONS OF A MONOCLONAL-ANTIBODY RECOGNIZING AN ANTIGEN RESTRICTED TO NEUROECTODERMAL TISSUES [J].
ALLAN, PM ;
GARSON, JA ;
HARPER, EI ;
ASSER, U ;
COAKHAM, HB ;
BROWNELL, B ;
KEMSHEAD, JT .
INTERNATIONAL JOURNAL OF CANCER, 1983, 31 (05) :591-598
[2]  
BODEY B, 1989, 12TH P EUR C PATH PO
[3]  
BODEY B, 1988, 8TH P INT C HIST CYT
[4]  
BOURNE SP, 1986, MEDULLOBLASTOMA CLIN, P87
[5]   CROSS-REACTIVITY BETWEEN HUMAN HEMATOPOIETIC-CELLS AND BRAIN-TUMORS AS DEFINED BY MONOCLONAL-ANTIBODIES [J].
BUDKA, H ;
MAJDIC, O ;
KNAPP, W .
JOURNAL OF NEURO-ONCOLOGY, 1985, 3 (02) :173-&
[6]  
BULLARD DE, 1986, SEMIN ONCOL, V13, P94
[7]   MOLECULAR GENETIC-MARKERS IN LYMPHOPROLIFERATIVE DISORDERS [J].
BURNS, BF .
CLINICAL BIOCHEMISTRY, 1989, 22 (01) :33-39
[8]   CELL-SURFACE ANTIGENS OF HUMAN ASTROCYTOMA DEFINED BY MOUSE MONOCLONAL-ANTIBODIES - IDENTIFICATION OF ASTROCYTOMA SUBSETS [J].
CAIRNCROSS, JG ;
MATTES, MJ ;
BERESFORD, HR ;
ALBINO, AP ;
HOUGHTON, AN ;
LLOYD, KO ;
OLD, LJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (18) :5641-5645
[9]   THE BIOLOGY OF ASTROCYTOMA - LESSONS LEARNED FROM CHRONIC MYELOGENOUS LEUKEMIA - HYPOTHESIS [J].
CAIRNCROSS, JG .
JOURNAL OF NEURO-ONCOLOGY, 1987, 5 (02) :99-104
[10]  
COAKHAM HB, 1984, S AFR J SURG, V22, P13