TENDON COLLAGEN FIBRILLOGENESIS - INTRACELLULAR SUBASSEMBLIES AND CELL-SURFACE CHANGES ASSOCIATED WITH FIBRIL GROWTH

被引:200
作者
TRELSTAD, RL
HAYASHI, K
机构
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0012-1606(79)90166-0
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The fine structure of tendon fibroblasts in developing limbs of chick and mouse embryos have been examined to define the cellular features of collagen fibrillogenesisin vivo. Two structural features of the fibroblast which may relate to fibril assembly have been observed: intracellular aggregates resembling SLS (segment-long-spacing)-like aggregates of monomeric and dimeric lengths and deep recesses of the cell surface containing striated fibrils. A model is proposed which suggests that assembly of a collagen fibrilin vivo begins by formation of subassemblies inside the cell which then are excreted by exocytosis and added to a unique region at the fibril end. This end is closely associated with the cell surface in a manner which allows for cellular regulation of some parameters of fibril morphology. © 1979 Academic Press, Inc. All rights reserved.
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页码:228 / 242
页数:15
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