CHEMOENZYMATIC SYNTHESIS OF FMOC-PEPTIDE FRAGMENTS

被引：12

作者：

CHEN, ST

HSIAO, SC

CHANG, CH

WANG, KT

机构：

[1] Institute of Biological Chemistry, Academia Sinica, Taipei, 10098.

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 03期

关键词：

D O I：

10.1080/00397919208055416

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically pure Fmoc-peptide fragments have been prepared via dicyclohexylcarbodiimide coupling of N-protected amino acids with amino acid esters, followed by enzyme-catalyzed ester hydrolysis by alcalase with a high concentration of organic solvent in a high yield.

引用

页码：391 / 398

页数：8

共 19 条

[1]

ALIKSEIV B, 1981, HOPPESELERS Z PHYSL, V362, P1323

[2] SELF-INDICATING ACTIVATED ESTERS FOR USE IN SOLID-PHASE PEPTIDE-SYNTHESIS - FLUORENYLMETHOXYCARBONYLAMINO ACID-DERIVATIVES OF 3-HYDROXY-4-OXODIHYDROBENZOTRIAZINE [J].