MOLECULAR-CLONING OF HUMAN XPAC GENE HOMOLOGS FROM CHICKEN, XENOPUS-LAEVIS AND DROSOPHILA-MELANOGASTER

被引：27

作者：

SHIMAMOTO, T ^{[1
]}

KOHNO, K ^{[1
]}

TANAKA, K ^{[1
]}

OKADA, Y ^{[1
]}

机构：

[1] OSAKA UNIV,INST MOLEC & CELLULAR BIOL,SUITA,OSAKA 565,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 181卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)92070-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We cloned homologs of the human Seroderma Pigmentosum Group A complementing (XPAC) gene from chicken, Xenopus laevis and Drosophila melanogaster. A comparison of the amino acid sequences of these homologs with that of the human XPAC protein revealed that in the NH2-terminal domain there are only two conserved regions, one of which is presumed to function as the nuclear localization signal, whereas the COOH-terminal domain is highly conserved, the frequency of identical amino acids in all four XPAC proteins being 50%, and the four cysteine residues predicted to form a zinc-finger motif, and three other cysteine residues are all conserved. These results strongly suggest that the COOH-terminal domain containing a zinc-finger motif plays an important role in the function of these proteins. © 1991.

引用

页码：1231 / 1237

页数：7

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